Dangers of taking ibuprofen with prednisone. The following commentary comes from an independent investor or market observer as part of TheStreet’s guest contributor program, which is separat. . . . . . . . ibuprofen: 1-6 pills/day, (up to 1,200 mg/day) Nuprin®. . prednisone, naproxen, Cymbalta, meloxicam, ibuprofen, . . . . follow on from another thread about the dangers of ibuprofen . . . . Long term use of the painkiller ibuprofen when taken for more than five years . Prednisone Side E... more