Bactrim liver. . . . . Learn about the prescription medication Bactrim (Trimethoprim and Sulfamethoxazole . . Elderly adults: There may be an increased risk of severe side effects when Bactrim is taken by older people, especially in those who have impaired kidney and/or liver . . Acute liver failure. . can sulfameth trimethoprim treat a prostate infection - This drug can cause a. Do not take Bactrim if you have a condition called megaloblastic anemia due to folate deficiency or if you have liv... more