Augmentin and sulfa allergy. DRUG INTERACTIONS: Augmentin should be avoided by patients with an allergy to penicillin and other related . If I am allergic to penicillin and sulfa drugs, will I be . You should look into the possibility of an allergy to the antibiotic. . . Health question: Can you take augmentin if allergic to sulfa drugs? Answer below from this site . . its sulfa. Many people avoid the entire class of sulfa medications - although this may not be necessary. Find out more about h... more