Tamoxifen and welbutrin interactions. to treat and prevent some types of breast cancer. . Synthroid; Tramadol; Trazodone; Vicodin; Wellbutrin; Xanax; Zocor; ZoloftMedco just informed my family doctor, who prescribed Wellbutrin and my Oncologist, who prescribed Tamoxifen about the two drug interactions. I’d read on wellbutrin inhibiting tamoxifen. Consult your healthcare . . (PROZAC), paroxetine (PAXIL) and bupropion (WELLBUTRIN), could reduce the effect of tamoxifen . . . . . . . Prozac),... more