Is nexium stronger than prilosec. Unfortunately, Nexium works better than Prilosec for some people, and the prescription dose of Nexium is quite a bit stronger than the OTC dose of Prilosec. . . . Due to the fact that I've now tried Nexium, Prilosec, and Prevacid with no relief his . . that over-the-counter Prilosec is just as effective in treating heartburn and acid reflux disease as prescription drugs, such as Nexium . . . To me, that . . . is quite a bit stronger than the OTC dose of Prilos... more