Metformin and hepatic glucose production. However, it should be noted that the inhibitory action of metformin on hepatic glucose production was much more pronounced in AMPK-deficient hepatocytes, even at the . decrease in cellular ATP and a concomitant increase in AMP, which Foretz et al. . . Metformin decreases hepatic glucose production, decreases intestinal absorption of glucoseThe primary effect of metformin (Figure 1. Metformin’s beneficial effects on circulating lipids . . Understan... more