Azithromycin for severe acne. The azithromycin that . These findings suggest that azithromycin is a better alternative in patients with moderate to severe acne and has no serious side effects. . . . Oral antibiotics are the most widely administered drugs, which are prescribed as systemic therapy for treatment of moderate to severe acne vulgaris. . . presence of nodules or from a more severe form of acne, such as from nodular acne vulgaris or even from severe nodular acne vulgaris. . 00: Acne s... more