Intensify hydrocodone effects. Also, alcohol should be avoided while taking this drug because it may intensify the effects of this narcotic--both alcohol and hydrocodone depress or slow down the . . . MAOIs have been reported to intensify the effects of . . . I think you'll notice a slight increase in effect with the grapefruit juice. Acetaminophen Hydrocodone information from Drugs. If detoxification is done very rapidly, hydrocodone withdrawal can intensify. . . . The effects of alcohol on t... more