Metformin swellingHealth Issues > Drug Interactions . . . . . . . Best Answer: Swelling of the feet will not cause you to have a foot cut off. . 19 . . I saw the doctor this evening and she didn`t think the swelling was from the metformin. . . Comprehensive and accurate information about metformin and Swelling of the legs for consumers and professionalsGet emergency medical help if you have any of these signs of an allergic reaction to metformin: hives; difficult breathing; swelling of your... more