Hydrocodone and low sperm counts. . . I was up to 20-30 . . . Painkillers like codeine, hydrocodone, morphine or oxycodone are used to treat . . in the lower reproductive track thicker thereby making it difficult for the sperm to . . . . . . . I was strung out on it long ago. . . problem manifest by lower sperm counts and increased numbers of immature sperm . . 3 Responses to Does hydrocodone (loritab) affect sperm count? . . % Low Sperm Count: Hodgkin's: MOPP: 85%: Hodgkin's: ABVD: 0: Testes ... more