Hydrocodone from codeine. (It activates the opiate receptors weakly. . Don't just sit there scratching your head, find useful info on Codeine on eHow. 1) Potency: Codeine is a weak agonist. . . ) It is . . Best Answer: Hydrocodone is alot like codeine, except that codeine is a natural derivative of opium plants whilst hydrocodone is synthetic. Hydrocodone is also much . An experience with Hydrocodone & Codeine. It's almost inactive on it's . A synthetic narcotic analgesic similar to but mo... more