Prednisone and mouth sores. . . . Some of these include the use of prednisone to . Cold SoresCanker Sores (Aphthous Mouth Ulcers) Report #7041 . NOTE: All sore “mouth” vaccines contain live virus which, if proper protective . may also be treated with a medication called dexamethasone in a mouth rinse, or prednisone . . . In severe cases a short course of systemic steroid (prednisone, etc. . Specific treatment for an attack involves corticosteroids (prednisone-like . . . . Oral Diseas... more