Can prednisone make you feel jittery. . . . But they shouldn't be overused: High doses can make you feel jittery, and the products have . . . . effects and experiences with PredniSONE by users like you. . . and that is a very large dose. . . which helped relieve some of it but then it made me jittery . Best Answer: it certainly can do that. . . . . . . . . . . . Until then, make the best of life that you can, I do have o2 only to . . . . of the support you have, that can make . . . Also, make ... more