sertraline effect dopamine Sertraline also . Dopamine One property of sertraline is that it appears to be also a minor inhibitor of dopamine reuptake. . . . It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline . . Sertraline is also a dopamine reuptake inhibitor, with 1% of its SRI potency, and a . Best Answer: Zoloft (sertraline) has (for all practical purposes) no impact on dopamine however it does technically effect dopamine as exp... more