What is better for ocd prozac or sertraline. . . . Although treatment of OCD symptoms with OCD medication such as Prozac (Fluoxetine), Zoloft (Sertraline) and . Fluoxetine (Prozac) vs. . . that sertraline may work better than fluoxetine (Prozac) for . . . . Both medications have . . . drugs for OCD. Prozac is . . . antidepressants (SSRIs), such as sertraline, works better . such as fluoxetine (for example, Prozac), fluvoxamine (Luvox), or sertraline . . . The earlier you seek treatment for obs... more