Wellbutrin melatonin interactionSeroquel; Synthroid; Tramadol; Trazodone; Vicodin; Wellbutrin; Xanax; Zocor; ZoloftThe interaction caused by grapefruit compounds lasts for up to 24 hours and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before . . Is it fairly safe while on Wellbutrin? I tried Melatonin and that did absolutely zero (it use . . . . . Consult your pharmacist. Melatonin; Psyllium; S-Adenosylmethionine (SAMe) St. In place of GABA, melatonin h... more