Seroquel and smoking. There is a remarkable letter to the editor in this month's American Journal of Psychiatry about Seroquel abuse in an Ohio . anyone ever do this? i have 100mg pills. 25mg before i go . Best Answer: Some of the SEVERE side effects of Seroquel include: restlessness, tremors and uncontrolled arm/leg movements (jerking). Eletta Hansen explains some facts about smoking,. alan galbraith, nicotine withdrawal, seroquel: Dear Lynne Seroquel is unlikely to be producing any of these ... more