Prednisone insomnia treatment. . . As with most steroid medications, prednisone can be . . . . . Other possible short-term effects include euphoria, insomnia, headaches, muscle . you need to know about sleeplessness caused by prednisone, including the most common causes and treatments. purposes only and is not a substitute for medical advice or treatment for any . If you need long-term prednisone treatment, your doctor may prescribe . . . Side effects including increased appetite, weight gain,... more