Side effects of high dose prednisone. . . . (See side effects. 7 - There are mild to severe side effects associated with prednisone use. . . Includes prednisone side effects . therapy, the dose of prednisone must be tapered (lowered gradually) to allow the adrenal glands time to recover. . may increase the clearance of chronic high . At a high dosage, prednisone may cause fluid retention and high blood . term, high dose prednisone (60mg x 5 days, 40mg x 5days and 20mg x 5 days) My question is,... more