Immune system after prednisone. . . Posted in the Prednisone (generic), Deltasone, Orasone ForumMy husband developed pneumonia after taking prednisone. When prednisone is discontinued after a period of prolonged . This drug may affect your immune system . . I have a very sick male 10 year old cat who has been on Prednisone for most of his life due to a "bad immune system" after a toxic dose of antibiotics when he was about a . . . . . . . . 1 - Prednisone reduces inflammation and supresses the... more