lunesta and interactionsLearn about the prescription medication Lunesta (Eszopiclone), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. suggests that eszopiclone disposition should not be affected by drug-drug interactions . . What other drugs affect Lunesta (Eszopiclone)? Before taking eszopiclone, tell your doctor if you are taking any of the following drugs: rifampin (Rifadin, Rifater, Rifamate . Includes Celebrex (celecoxib), clonazepam, Cymbalt... more