Ciprofloxacin and sinus infectionDiseases & Conditions Question: Can You Take Cipro 500mg For Sinus Infection? Yes,the dr. . Ciprofloxacin is an antibiotic in a group of drugs called fluoroquinolones. if you take it without really needing it, you can set yourself up for resistant bacteria . . . Has given me cipro for a sinus infection. I was just recently given Cipro 500mg for a sinus infection. I had tried Zithromax and Augmentin and after 5 weeks, still have sinus congestion and. Ciprofl... more