Is there an alternative to tamoxifen. Alternatives to Tamoxifen. Are there any good alternatives to Tamoxifen for breast cancer (after having chemotherapy and radiation therapy)? The majority of breast and uterine cancers are estrogen . Is there an alternative to an SSRI (such as an older antidepressant) which will not interfere with Tamoxifen, Zoladex or Zometa? (St John's Wort, it works in the same way . . While the cancer establishment continues to invest vast amounts of . Best Answer: Ther... more